Olympus Labs K1NGS SLAYER Description
What is Olympus Labs K1NGS SLAYER
Olympus Labs K1NGS SLAYER is a natural muscle builder that promotes gains in size and strength, alongside improved sleep and better digestion in different specially targeted ways. Another benefit of K1NGS SLAYER is nutrient uptake and muscle recovery. While that is amazing on its own it will get so much better from there with improved body composition due to increased energy metabolism. The key aspect of all the aforementioned benefits is they will occur to a significant degree, certainly more than any natural muscle builder on the market. These targeted pathways and how this unique sport supplement works and what makes it interesting is explained further down.
How Olympus Labs K1NGS SLAYER works
Olympus Labs K1NGS SLAYER contains four effective ingredients supported by clinical data to induce significant muscle gain, where the clinical dose of 2g of Korean Mistletoe Extract replaces Robuvit®. The remaining components of the formula is essentially unchanged; 750mg of Hesperidin Methyl Chalcone, 600mg of Gentian Root extract and 300mg of Atractylodis Lanceae extract (20% Atractylodin). Gentian Root significantly improves digestion and nutrient uptake. Hesperidin and Atractylodin are potent stimulators of ghrelin secretion, the link connecting somatic growth and body composition with energy metabolism. Korean Mistletoe Extract is another innovative ingredient that Olympus Labs brings to the supplement industry. It has incredible potential as a stimulator of myogenesis, mitochondrial function and IGF-1 receptor signalling. Those pathways ultimately result in increased endurance, increases in skeletal muscle mass and reduction of muscle breakdown. It is quite amazing to have all these properties in one ingredient at the magnitude that KME provides, let alone one that is completely natural.
Ghrelin is an endogenous ligand, GHS-R1a, of the GH secretagogue receptorthat can cause a significant increase in appetite. In fact, Ghrelin is the only hormone that exhibits this appetite enhancement, or orexigenic effect, following peripheral administration. In addition, ghrelin exhibits a variety of actions, including stimulation of GH secretion, gastric motility, and gastric acid secretion, as well as induction of a positive energy balance. This hormone, predominantly expressed and secreted by the stomach, has a dual action on GH secretion and food intake. It is believed to be the link connecting somatic growth and body composition with energy metabolism.
I-GF-1, identified in 1957, is a small peptide consisting of 70 amino acids which share some structural similarities to insulin. The I-GF-1 receptor gene is expressed by almost all tissues and cells during prenatal development. The activated I-GF-1 receptor is capable of phosphorylating other substances leading to protein kinases which regulate cellular pathways. Research in both children and adults has demonstrated that I-GF-1 raises serum alkaline phosphatase, which is an indicator of osteoblastic activity and linked to muscle development. Although different than GH, I-GF-1 receptor signalling has been proven to result in muscle growth.
Mistletoe is a semi-parasitic plant that grows on various trees and that has been used for centuries to treat several human ailments. It is believed to have immunostimulatory, anti-diabetic, and anti-obesity properties. There are several extracts of Mistletoe and the chemical composition of them depends on the species of the host tree, harvest time and extract preparation. Recent research has focused on Korean mistletoe extract (KME) for use as a treatment for the prevention and reversal of muscle wasting conditions. The research on KME is nothing short of exceptional and quite beneficial for athletes. It has been shown to increase endurance exercise by potentiating mitochondrial function and increase muscle hypertrophy while preventing muscle atrophy. It induced those results by stimulating myogenesis, phosphorylation of Akt signaling pathway, PGC-1α and GLUT4 expression perfect partner for higher IGF-1 expression stimulated by Hesperidin and Atractylodin) and inhibited atrogin-1. Although KME is derived from a semi-parasitic plant, clinical studies in humans have found no negatives side effects. In fact, studies have shown it has been well tolerated and there have been no indications of liver or kidney toxicity.
A randomized controlled trial examined whether a combination of Korean mistletoe extract (KME) supplement and exercise affected muscle mass, muscle function, and targeted molecular expressions. Sixty-seven subjects were assigned to placebo, low-dose (1 g/d), or high-dose (2 g/d) of KME for 12 weeks. The body composition was significantly changed in the high-dose group during the intervention period as determined by skeletal muscle mass, fat free mass, soft lean mass, skeletal muscle index, fat-free mass index, percent body fat, and fat mass to lean mass ratio. Knee strength measurements demonstrated a significant effect in the KME groups compared to the placebo group, which was more pronounced after adjusting for age, gender, protein, and energy intake. The dynamic balance ability was remarkably improved in the high-dose group over a 12-week period as determined a fast walk and ordinary walk test. Consistent with these results, RT-PCR, multiplex analyses, and immunocytofluorescence staining revealed that a high-dose KME supplementation was effective for suppressing intracellular pathways related to muscle protein degradation, but stimulating those related to myogenesis. In particular, significant differences were found in atrogin-1 mRNA, myogenin mRNA and i-gf-1 receptor phosphorylation at a single administration and a 12-week administration. These results suggest that KME supplementation together with resistance exercise may be useful in suppressing the age-related loss of muscle mass and strength.
A clinical study examined the expression pattern of several genes concerned with muscle physiology in C2C12 myotubes (mice) cells to identify whether KME inhibits muscle atrophy or promotes muscle hypertrophy. KME induced the mRNA expression of SREBP-1c, PGC-1α, and GLUT4, known positive regulators of muscle hypertrophy, in C2C12 cells. On the contrary, KME reduced the expression of Atrogin-1, which is directly involved in the induction of muscle atrophy. In animal models, KME mitigated the decrease of muscle weight in denervated mice. The expression of Atrogin-1 was also diminished in those mice. Moreover, KME enhanced the grip strength and muscle weight in long-term feeding mice. These results suggest that KME has beneficial effects on muscle atrophy and muscle hypertrophy.
An study was conducted to examine whether KME could increase mitochondrial activity and exert an anti-fatigue effect in mice. KME treatment significantly increased the mitochondrial oxygen consumption rate (OCR) in L6 cells and increased the expression of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and silent mating type information regulation 2 homolog 1 (SIRT1), two major regulators of mitochondria function, in C2C12 cells. In the treadmill test, KME-treated mice could run 2.5-times longer than chow-fed control mice. Additionally, plasma lactate levels of exhausted mice were significantly lower in the KME-treated group. In addition, the swimming time to exhaustion of mice treated with KME was prolonged by as much as 212% in the forced-swim test. Liver and kidney histology was similar between the KME-treated and phosphate-buffered saline-treated animals, indicating that KME was nontoxic. These results show that KME induces mitochondrial activity, possibly by activating PGC-1α and SIRT1, and improves the endurance of mice, strongly suggesting that KME has great potential as a novel mitochondria-activating agent.
Hesperidin is a flavanone glycoside or a sugar molecule consisting of the flavone hesperetin bound to the disaccharide rutinose. It is naturally occurring in citrus fruits including oranges, tangerines and grapefruits. Hesperidin has been shown to influence several biological functions. It also has antibacterial, antiviral, and antifungal properties. In vivo studies have shown that hesperidin may also play a role in ghrelin secretion from the stomach through antagonism of the serotonin receptors.
A study with mouse muscle cells was performed to assess the in vivo and in vitro effect of hesperidin on myogenic differentiation (muscle tissue formation). The cells were analyzed in the presence and absence of hesperidin for the in vitro portion of the study using several lab testing methods, including reporter gene assays, immunoblotting, RT-PCR and DNA pull-down assays. In vivo, the effects of hesperidin were assessed using the freeze injury-induced muscle regeneration model in mice and daily injections of hesperidin for 6 days. Hesperidin promoted myogenic differentiation, in a dose-dependent manner, by increasing myogenin gene expression. Myogenin is a gene transcriptor in mice that plays a critical role in the development of functional skeletal muscle. Hesperidin increased myogenin and muscle creatine kinase gene expression during myogenic differentiation from C3H10T1/2 mesenchymal stem cells in a MyoD-dependent manner and accelerated in vivo muscle regeneration induced by muscle injury. These results indicate hesperidin can play a beneficial role in promoting muscle regeneration, following injury.
Gentian Root is a a herbal bitter that is derived from the perennial, Gentiana lutea L. It has traditionally been used in the treatment of digestive disorders and is an ingredient of many proprietary medicines. It contains secoiridoid glucosides which are some of the most bitter compounds known and is used as a scientific basis for measuring bitterness. Gentiana lutea is known to have several biological effects, such as anti-oxidant, anti-tumor and hepatoprotective properties. Recent clinical research into Gentian root and other bitter compounds found that observed improvements in digestion and appetite may at least be partly ascribed to the bitter tonic effect. The increase in appetite that Gentian root provides can be attributed to its ability to stimulate ghrelin secretion. If you want grow you will need to get those macros in and the significant improvement in digestion that Gentiana lutea provides will make larger meals more tolerable. At the substantial dosage included in OR1GIN it will be extremely effective in that regard.
Atractylodin is a derivative of the Atractylodes herb, a member of the Asteraceae family. It can be found in Rikkunshito, a Japanese herbal plant. It has been traditionally used as treatment for several conditions including atrophy and flaccidity, arthralgia (joint pain) due to wind and dampness and loss of appetite. Similar to Gentian root, the effect on appetite that Atractylodin causes, is indicative of ghrelin secretion. As detailed in the study below, Atractylodin has been shown to be effective with hesperidin induced ghrelin receptor signaling.
Active components of rikkunshito, hesperidin and atractylodin, were given to rats to determine their efficacy as a treatment for anorexia–cachexiaé It is a syndrome that results in decreased food intake, weight loss, muscle tissue wasting and psychological distress, and this syndrome is a major source of increased morbidity and mortality in patients. Corticotropin-releasing factor (CRF) decreased the plasma level of acyl ghrelin, and its receptor antagonist, α-helical CRF, increased food intake of these rats. The serotonin 2c receptor (5-HT2cR) antagonist SB242084 decreased hypothalamic CRF level and improved anorexia, gastrointestinal (GI) dysmotility and body weight loss. The ghrelin receptor antagonist (D-Lys3)-GHRP-6 worsened anorexia and hastened death in rats. Ghrelin attenuated anorexia–cachexia in the short term, but failed to prolong survival, as did SB242084 administration. In addition, the herbal medicine rikkunshito improved anorexia, GI dysmotility, muscle wasting, and anxiety-related behavior and prolonged survival in animals and patients with . The appetite-stimulating effect of rikkunshito was blocked by (D-Lys3)-GHRP-6
Active components of rikkunshito, hesperidin and atractylodin potentiated ghrelin secretion and receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats. Our study demonstrates that the integrated mechanism underlying anorexia–cachexia involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF through the 5-HT2cR. Potentiation of ghrelin receptor signaling may be an attractive treatment for anorexia, muscle wasting and prolong survival in patients with anorexia–cachexia.
How to use Olympus Labs KNGS SLAYER
As a dietary supplement take 6 capsules of Olympus Labs K1NGS SLAYER (one serving) with your largest meal of the day. Do not exceed 6 capsules in a 24 hour time period.